| ID Source | ID |
|---|---|
| PubMed CID | 2944626 |
| CHEMBL ID | 1391644 |
| CHEBI ID | 123343 |
| Synonym |
|---|
| HMS1765L05 |
| MLS000099433 |
| smr000074003 |
| 1-(4-phenoxybutanoyl)-4-(2-pyridinyl)piperazine |
| 4-phenoxy-1-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one |
| STK225804 |
| CHEBI:123343 |
| MLS002541986 |
| AKOS001049752 |
| 4-phenoxy-1-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one |
| HMS2174J06 |
| CHEMBL1391644 |
| 4-phenoxy-1-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone |
| Q27213052 |
| SR-01000267687-1 |
| sr-01000267687 |
| Z26735534 |
| Class | Description |
|---|---|
| piperazines | |
| pyridines | Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 0.0251 | 20.2376 | 39.8107 | AID893 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 0.0251 | 20.2376 | 39.8107 | AID893 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.1838 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 15.9323 | 0.0072 | 15.7588 | 89.3584 | AID411; AID588342 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 5.1296 | 0.0041 | 10.8903 | 31.5287 | AID504466; AID504467 |
| TDP1 protein | Homo sapiens (human) | Potency | 25.9290 | 0.0008 | 11.3822 | 44.6684 | AID686978 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 35.4813 | 0.0112 | 12.4002 | 100.0000 | AID1030 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 5.0119 | 0.0013 | 18.0743 | 39.8107 | AID926; AID938 |
| P53 | Homo sapiens (human) | Potency | 3.9811 | 0.0731 | 9.6858 | 31.6228 | AID504706 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 22.3872 | 0.0165 | 25.3078 | 41.3999 | AID602332 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 1.2589 | 0.0126 | 2.4518 | 25.0177 | AID485313 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.2593 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.1189 | 0.0398 | 16.7842 | 39.8107 | AID995 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.8913 | 0.0002 | 2.6215 | 31.4954 | AID485297 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 14.1254 | 0.0103 | 23.8567 | 63.0957 | AID2662 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 12.9244 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.1254 | 0.1259 | 12.2344 | 35.4813 | AID1458 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|---|---|---|---|---|---|
| dimethylphenylpiperazinium iodide | [no description available] | low | 0 | 0 | piperazines | |
| 1-(2-methoxyphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| bmy 7378 | [no description available] | low | 0 | 0 | piperazines | |
| cetirizine | [no description available] | low | 0 | 0 | ether; monocarboxylic acid; monochlorobenzenes; piperazines | anti-allergic agent; environmental contaminant; H1-receptor antagonist; xenobiotic |
| dipropizine | [no description available] | low | 0 | 0 | piperazines | |
| itraconazole | [no description available] | low | 0 | 0 | piperazines | |
| 5-isoquinolinesulfonic acid [4-[2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester | [no description available] | low | 0 | 0 | piperazines | |
| naftopidil | [no description available] | low | 0 | 0 | piperazines | |
| piperazine | [no description available] | low | 0 | 0 | azacycloalkane; piperazines; saturated organic heteromonocyclic parent | anthelminthic drug |
| prazosin | [no description available] | low | 0 | 0 | aromatic ether; furans; monocarboxylic acid amide; piperazines; quinazolines | alpha-adrenergic antagonist; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor |
| quipazine | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| terazosin | [no description available] | low | 0 | 0 | furans; piperazines; primary amino compound; quinazolines | alpha-adrenergic antagonist; antihypertensive agent; antineoplastic agent |
| urapidil | [no description available] | low | 0 | 0 | piperazines | |
| n-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyclohexanecarboxamide | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2-pyridinyl)-1-piperazinyl]-(3,4,5-trimethoxyphenyl)methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| almitrine | [no description available] | low | 0 | 0 | piperazines; triamino-1,3,5-triazine | central nervous system stimulant |
| etoperidone | [no description available] | low | 0 | 0 | piperazines | |
| ziprasidone | [no description available] | low | 0 | 0 | 1,2-benzisothiazole; indolones; organochlorine compound; piperazines | antipsychotic agent; dopaminergic antagonist; histamine antagonist; muscarinic antagonist; psychotropic drug; serotonergic antagonist |
| antrafenine | [no description available] | low | 0 | 0 | piperazines | |
| mepiprazole | [no description available] | low | 0 | 0 | piperazines | |
| niaprazine | [no description available] | low | 0 | 0 | piperazines | |
| way 100135 | [no description available] | low | 0 | 0 | piperazines | |
| bp 554 | [no description available] | low | 0 | 0 | piperazines | |
| gr 144053 | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(4-methoxyphenyl)-1-piperazinyl]pyrimidine | [no description available] | low | 0 | 0 | piperazines | |
| 2-(4-methyl-1-piperazinyl)aniline | [no description available] | low | 0 | 0 | piperazines | |
| 1-(4-fluorophenyl)sulfonyl-4-(2-methoxyphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| ar-c239 | [no description available] | low | 0 | 0 | piperazines | |
| 2-[2-[4-(2-fluorophenyl)-1-piperazinyl]-2-oxoethyl]-1,1-dioxo-1,2-benzothiazol-3-one | [no description available] | low | 0 | 0 | piperazines | |
| 2-[(5,5-dimethyl-6H-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)thio]-1-[4-(2-methoxyphenyl)-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(1-tert-butyl-5-tetrazolyl)-thiophen-2-ylmethyl]-4-(2,3-dimethylphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 3-chloro-1-cyclohexyl-4-(4-methyl-1-piperazinyl)pyrrole-2,5-dione | [no description available] | low | 0 | 0 | maleimides; piperazines | |
| N-[4-[3-[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-2-hydroxypropoxy]phenyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 4-[4-[[1-[(4-methoxyphenyl)methyl]-5-tetrazolyl]-(3-pyridinyl)methyl]-1-piperazinyl]phenol | [no description available] | low | 0 | 0 | piperazines | |
| 1-[1-(1-cyclopentyl-5-tetrazolyl)-2-methylpropyl]-4-(2-fluorophenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 3-[(1-cyclopentyl-5-tetrazolyl)-[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-7-methyl-1H-quinolin-2-one | [no description available] | low | 0 | 0 | piperazines | |
| 1-methyl-4-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-5-pyrrolo[3,2-b]pyrrolecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | piperazines | |
| 6-methyl-2-[4-[oxo(thiophen-2-yl)methyl]-1-piperazinyl]-3-quinolinecarbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| [5-(2-furanyl)-7-(trifluoromethyl)-2-pyrazolo[1,5-a]pyrimidinyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-(4-fluorophenyl)-4-[[1-(2-phenylethyl)-5-tetrazolyl]-thiophen-2-ylmethyl]piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 6,7-dimethoxy-2-[[2-[4-(4-methoxyphenyl)-1-piperazinyl]-2-oxoethyl]thio]-3-quinolinecarbonitrile | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-(2-methoxyphenyl)-1-piperazinyl]-2-[[5-(2-methyl-3-furanyl)-1,3,4-oxadiazol-2-yl]thio]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-[1-[1-(1,3-benzodioxol-5-ylmethyl)-5-tetrazolyl]-2-methylpropyl]-4-phenylpiperazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-[(5,5-dimethyl-6H-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)thio]-1-(4-phenyl-1-piperazinyl)ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 3-chloro-4-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]-N,N-dimethylbenzenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| 2-(3-methylphenoxy)-N-[4-(4-methylsulfonyl-1-piperazinyl)phenyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-(2-methoxyphenyl)-4-[(4-methylphenyl)-(1-propan-2-yl-5-tetrazolyl)methyl]piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 4-[4-[(1-cyclopentyl-5-tetrazolyl)-pyridin-4-ylmethyl]-1-piperazinyl]phenol | [no description available] | low | 0 | 0 | piperazines | |
| 5,8-dimethoxy-4-(4-methyl-1-piperazinyl)-2-(trifluoromethyl)quinoline | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-phenyl-4-[[1-(phenylmethyl)-5-tetrazolyl]-(3-pyridinyl)methyl]piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(3,4-dimethoxyphenyl)-[1-(thiophen-2-ylmethyl)-5-tetrazolyl]methyl]-4-phenylpiperazine | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(1-cyclopentyl-5-tetrazolyl)-thiophen-2-ylmethyl]-4-(2-methoxyphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(2-methoxyphenyl)-[1-(2-phenylethyl)-5-tetrazolyl]methyl]-4-phenylpiperazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thio]-1-(4-phenyl-1-piperazinyl)ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 8-(2-furanyl)-6-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-3,3-dimethyl-1,4-dihydrothiopyrano[3,4-c]pyridine-5-carbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 3-[[2-[4-(3-chlorophenyl)-1-piperazinyl]-1-oxoethyl]amino]-1H-indole-2-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(4-methylphenyl)methyl]-4-[4-(4-methylphenyl)-1-piperazinyl]pyrazolo[3,4-d]pyrimidine | [no description available] | low | 0 | 0 | piperazines | |
| 7-hexyl-3-methyl-8-(4-phenyl-1-piperazinyl)purine-2,6-dione | [no description available] | low | 0 | 0 | piperazines | |
| 8-[4-(3-chlorophenyl)-1-piperazinyl]-3-methyl-7-pentylpurine-2,6-dione | [no description available] | low | 0 | 0 | piperazines | |
| 6-hydroxy-7-phenyl-4-[(4-phenyl-1-piperazinyl)methyl]-1-benzopyran-2-one | [no description available] | low | 0 | 0 | piperazines | |
| 7-(3-chlorophenyl)-2-(4-phenyl-1-piperazinyl)-7,8-dihydro-6H-quinazolin-5-one | [no description available] | low | 0 | 0 | piperazines | |
| N-[1-methyl-2-[2-(4-phenyl-1-piperazinyl)ethyl]-5-benzimidazolyl]-2-furancarboxamide | [no description available] | low | 0 | 0 | piperazines | |
| 7-butyl-8-[[4-(3-chlorophenyl)-1-piperazinyl]methyl]-1,3-dimethylpurine-2,6-dione | [no description available] | low | 0 | 0 | piperazines | |
| 2-methyl-3-phenyl-5-propyl-7-[4-(2-pyridinyl)-1-piperazinyl]pyrazolo[1,5-a]pyrimidine | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N2-(4-fluorophenyl)-6-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1,3,5-triazine-2,4-diamine | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 4-(3,4-dihydro-2H-quinolin-1-yl)-6-[(4-phenyl-1-piperazinyl)methyl]-1,3,5-triazin-2-amine | [no description available] | low | 0 | 0 | piperazines | |
| 8-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-1,3-dimethyl-7-[2-(4-morpholinyl)ethyl]purine-2,6-dione | [no description available] | low | 0 | 0 | piperazines | |
| 5-[(2-chloro-6-fluorophenyl)methyl]-N-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-1,3,4-oxadiazole-2-carboxamide | [no description available] | low | 0 | 0 | piperazines | |
| (3,4-dimethylphenyl)-(4-phenyl-1-piperazinyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| 4-(4-propan-2-yl-1-piperazinyl)phenol | [no description available] | low | 0 | 0 | piperazines | |
| 1-(2,4-dimethylphenyl)-4-(1-piperidinylsulfonyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-(4-aminophenyl)-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-(cyclohexylmethyl)-4-phenylpiperazine | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(3,4-dimethoxyphenyl)methyl]-4-(2,3-dimethylphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 1-(2-methoxyphenyl)-4-(3-thiophenylmethyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(4-phenyl-1-piperazinyl)methyl]-2-naphthalenol | [no description available] | low | 0 | 0 | piperazines | |
| 4-[[4-(2,5-dimethylphenyl)-1-piperazinyl]methyl]-2-methoxyphenol | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2-methylphenyl)-1-piperazinyl]-(4-nitrophenyl)methanethione | [no description available] | low | 0 | 0 | piperazines | |
| 4-(methoxymethyl)-6-methyl-2-(4-phenyl-1-piperazinyl)-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-2-benzo[cd]indolone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-propylsulfonyl-4-(2-pyridinyl)piperazine | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-[4-(2,3-dimethylphenyl)-1-piperazinyl]-2-methyl-1-propanone | [no description available] | low | 0 | 0 | piperazines | |
| 1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1,3-dimethyl-8-(4-phenyl-1-piperazinyl)-7H-purine-2,6-dione | [no description available] | low | 0 | 0 | piperazines | |
| 2-[[2-[4-(4-chlorophenyl)-1-piperazinyl]-2-oxoethyl]thio]-3-ethyl-4-quinazolinone | [no description available] | low | 0 | 0 | piperazines | |
| 2-[[5-[(2,6-dimethylphenoxy)methyl]-4-ethyl-1,2,4-triazol-3-yl]thio]-1-(4-phenyl-1-piperazinyl)ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 6-(4-benzoyl-1-piperazinyl)-3,3-dimethyl-8-propan-2-yl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-(2-fluorophenyl)-4-[(6-nitro-1,3-benzodioxol-5-yl)methyl]piperazine | [no description available] | low | 0 | 0 | piperazines | |
| N-(3,5-dimethylphenyl)-4-(3-methoxyphenyl)-1-piperazinecarbothioamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-(4-chloro-3-methoxyphenyl)sulfonyl-4-phenylpiperazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-(4-chlorophenoxy)-N-[4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]phenyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]phenyl]-2-(3-methylphenoxy)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[4-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]phenyl]propanamide | [no description available] | low | 0 | 0 | piperazines | |
| [3-amino-4-(methoxymethyl)-6-methyl-2-thieno[2,3-b]pyridinyl]-(4-phenyl-1-piperazinyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2-methoxyphenyl)-1-piperazinyl]-[5-(4-methylphenyl)-3-isoxazolyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| 4-[4-(benzenesulfonyl)-1-piperazinyl]-2-methylquinoline | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-(3,4-dimethoxyphenyl)sulfonyl-4-(2-methoxyphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-[2-[4-(4-fluorophenyl)-1-piperazinyl]-2-oxoethoxy]benzoic acid methyl ester | [no description available] | low | 0 | 0 | piperazines | |
| 1-[1-ethyl-4-[4-(4-methoxyphenyl)-1-piperazinyl]-6-methyl-2-sulfanylidene-5-pyrimidinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| [4-(4-fluorophenyl)-1-piperazinyl]-(2-methyl-3-pyrazolyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| 2-(4-bromophenyl)-1-[4-(2-pyridinyl)-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| [4-(2-methylphenyl)-1-piperazinyl]-(5-propyl-3-thiophenyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| (4-chlorophenyl)-[4-(7-chloro-4-quinolinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 2-(4-chloro-3,5-dimethylphenoxy)-N-[4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]phenyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(5-methyl-2-propan-2-ylphenoxy)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-(3,4-dimethoxyphenyl)sulfonyl-4-(2,6-dimethylphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2,3-dimethylphenyl)-1-piperazinyl]-(3,4,5-trimethoxyphenyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| 2-(1-imidazolyl)-4-phenyl-6-(4-phenyl-1-piperazinyl)-1,3,5-triazine | [no description available] | low | 0 | 0 | piperazines | |
| 7-chloro-4-[4-(3,4-dimethylphenyl)sulfonyl-1-piperazinyl]quinoline | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-[1-ethyl-4-[4-(4-fluorophenyl)-1-piperazinyl]-6-methyl-2-sulfanylidene-5-pyrimidinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| N-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]carbamic acid phenyl ester | [no description available] | low | 0 | 0 | piperazines | |
| 1-[1-ethyl-6-methyl-4-(4-phenyl-1-piperazinyl)-2-sulfanylidene-5-pyrimidinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 4-[[4-(2,3-dimethylphenyl)-1-piperazinyl]methyl]-2,6-dimethoxyphenol | [no description available] | low | 0 | 0 | piperazines | |
| 1-(3-chlorophenyl)-4-[(3,4,5-trimethoxyphenyl)methyl]piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-[5-(2-aminophenyl)-2-tetrazolyl]-1-[4-(4-methoxyphenyl)-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(2-methoxyphenyl)-1-piperazinyl]-N-[4-(1-tetrazolyl)phenyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 7-methoxy-2-[4-[(2-methylphenyl)-oxomethyl]-1-piperazinyl]-3-quinolinecarbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 5-cyano-2-phenyl-6-[4-(2-pyridinyl)-1-piperazinyl]-3-pyridinecarboxylic acid ethyl ester | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-[(4-methylphenyl)methyl]-4-[4-(2-methylphenyl)-1-piperazinyl]pyrazolo[3,4-d]pyrimidine | [no description available] | low | 0 | 0 | piperazines | |
| 1-[(4-chlorophenyl)methyl]-4-[4-(2-methylphenyl)-1-piperazinyl]pyrazolo[3,4-d]pyrimidine | [no description available] | low | 0 | 0 | piperazines | |
| 4-[4-(3-chlorophenyl)-1-piperazinyl]aniline | [no description available] | low | 0 | 0 | piperazines | |
| N-[(2-furanylmethylamino)-oxomethyl]-2-[4-(4-hydroxyphenyl)-1-piperazinyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[(tert-butylamino)-oxomethyl]-2-[4-(4-hydroxyphenyl)-1-piperazinyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[(tert-butylamino)-oxomethyl]-2-[4-(3-chlorophenyl)-1-piperazinyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 4-(4-hydroxyphenyl)-N-(phenylmethyl)-1-piperazinecarbothioamide | [no description available] | low | 0 | 0 | piperazines | |
| [4-(5-chloro-2-methylphenyl)-1-piperazinyl]-(2-ethoxy-3-pyridinyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-[[4-(2,4,6-trimethylphenyl)-1-piperazinyl]sulfonyl]azepane | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2-ethoxyphenyl)-1-piperazinyl]-(1-oxido-4-pyridin-1-iumyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| 3-[(4-chlorophenyl)thio]-1-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-propanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-(4-hydroxyphenyl)-1-piperazinyl]-3-(1H-indol-3-yl)-1-propanone | [no description available] | low | 0 | 0 | piperazines | |
| 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| [4-(4-hydroxyphenyl)-1-piperazinyl]-[2-methoxy-4-(methylthio)phenyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| 2-(2,3-dihydro-1H-inden-5-yloxy)-1-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-2-[4-(4-hydroxyphenyl)-1-piperazinyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 3-[[4-(4-fluorophenyl)-1-piperazinyl]sulfonyl]benzoic acid [2-(methylamino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | piperazines | |
| 2-chloro-N-(2,3-dihydro-1H-inden-5-yl)-5-[(4-phenyl-1-piperazinyl)sulfonyl]benzamide | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(2-hydroxyphenyl)-1-piperazinyl]-N-(5-methyl-3-isoxazolyl)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[(cyclopentylamino)-oxomethyl]-2-[4-(2-hydroxyphenyl)-1-piperazinyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| [4-(3-chlorophenyl)-1-piperazinyl]-(2,5-dimethyl-3-furanyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| 3-[3-[4-(3-chlorophenyl)-1-piperazinyl]-3-oxopropyl]-4-pyrido[2,3-d]pyrimidinone | [no description available] | low | 0 | 0 | piperazines | |
| Ethyl 4-(2-methoxyphenyl)piperazine-1-carboxylate | [no description available] | low | 0 | 0 | piperazines | |
| N-tert-butyl-4-[3-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 2-amino-6-[4-(6-chloro-2-pyridinyl)-1-piperazinyl]pyridine-3,5-dicarbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| (3,5-dichlorophenyl)-[4-[2-(trifluoromethyl)-4-quinolinyl]-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| (4-methylphenyl)-[4-[4-nitro-2-(1-pyrrolyl)phenyl]-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| N-(4-butyl-2-methylphenyl)-N'-[4-(4-methylpiperazino)phenyl]urea | [no description available] | low | 0 | 0 | piperazines | |
| 2-({2-[4-(4-Fluorophenyl)piperazino]-2-oxoethyl}sulfanyl)acetic acid | [no description available] | low | 0 | 0 | piperazines | |
| 3-[5-[[4-(2-pyridinyl)-1-piperazinyl]sulfonyl]-2-thiophenyl]isoxazole | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 4-[4-(3-bromophenyl)sulfonyl-1-piperazinyl]-7-chloroquinoline | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 3-[4-(4-chlorophenyl)-1-piperazinyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | [no description available] | low | 0 | 0 | piperazines | |
| 1-(4-fluorophenyl)-3-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyrrolidine-2,5-dione | [no description available] | low | 0 | 0 | piperazines | |
| 1-(5-bicyclo[2.2.1]hept-2-enylmethyl)-4-[3-(trifluoromethyl)phenyl]piperazine | [no description available] | low | 0 | 0 | piperazines | |
| N-[2-(4-chlorophenoxy)ethyl]-5-(3,5-dimethyl-1-piperazinyl)-2-nitroaniline | [no description available] | low | 0 | 0 | piperazines | |
| 3,7-dimethyl-2-[4-(2-pyridinyl)-1-piperazinyl]quinoline | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 3-[2-[4-(2-chloro-4-nitrophenyl)-1-piperazinyl]ethoxy]-4-phenyl-1,2,5-oxadiazole | [no description available] | low | 0 | 0 | piperazines | |
| 3-phenyl-1-[4-(2-pyridinyl)-1-piperazinyl]-1-propanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-[2-nitro-4-(trifluoromethylsulfonyl)phenyl]-4-phenylpiperazine | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2-methoxyphenyl)-1-piperazinyl]-[4-[(phenylthio)methyl]phenyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| N-[[4-(4-nitrophenyl)-1-piperazinyl]-sulfanylidenemethyl]butanamide | [no description available] | low | 0 | 0 | piperazines | |
| N-cyclohexyl-4-(4-nitrophenyl)-1-piperazinecarbothioamide | [no description available] | low | 0 | 0 | piperazines | |
| 6-amino-4-[3-[[4-(4-fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile | [no description available] | low | 0 | 0 | piperazines; pyranopyrazole | |
| N-(4-fluorophenyl)-4-(4-nitrophenyl)-1-piperazinecarbothioamide | [no description available] | low | 0 | 0 | piperazines | |
| 4-[2-nitro-5-[4-(phenylmethyl)sulfonyl-1-piperazinyl]phenyl]morpholine | [no description available] | low | 0 | 0 | piperazines | |
| 5-(4-ethylsulfonyl-1-piperazinyl)-2-nitro-N-(3-pyridinylmethyl)aniline | [no description available] | low | 0 | 0 | piperazines | |
| 1-adamantyl-[4-(2-fluorophenyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(4-nitrophenyl)-1-piperazinyl]-N-(2-pyridinyl)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-(2-adamantyl)-4-(4-ethylsulfonyl-1-piperazinyl)-3-nitrobenzamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-(3,4-dichlorophenyl)sulfonyl-4-[3-[(4-methyl-1,2,4-triazol-3-yl)thio]-4-nitrophenyl]piperazine | [no description available] | low | 0 | 0 | piperazines | |
| N-[3-chloro-4-[4-[oxo-(4-propoxyphenyl)methyl]-1-piperazinyl]phenyl]propanamide | [no description available] | low | 0 | 0 | piperazines | |
| 4-(4-nitrophenyl)-N-prop-2-enyl-1-piperazinecarbothioamide | [no description available] | low | 0 | 0 | piperazines | |
| 3-fluoro-N-[4-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]phenyl]benzenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-[3-[4-(2-chloro-5-methoxyphenyl)-1-piperazinyl]propyl]-3-(4-methylphenyl)urea | [no description available] | low | 0 | 0 | piperazines | |
| 1-(4-methoxy-2-nitrophenyl)-4-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(2-methyl-4-quinolinyl)-1-piperazinyl]-4-phenylthiazole | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N-[3-chloro-4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]phenyl]-2-(4-chlorophenyl)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 2-(4-chlorophenyl)-N-[4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]phenyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 2-[3-oxo-1-[[[oxo(thiophen-2-yl)methyl]amino]-sulfanylidenemethyl]-2-piperazinyl]acetic acid propan-2-yl ester | [no description available] | low | 0 | 0 | isopropyl ester; piperazines | |
| 2-[1-[[[(4-methoxyphenyl)-oxomethyl]amino]-sulfanylidenemethyl]-3-oxo-2-piperazinyl]acetic acid propan-2-yl ester | [no description available] | low | 0 | 0 | isopropyl ester; piperazines | |
| 1-(1,3-benzodioxol-5-yl)-3-[4-(4-hydroxyphenyl)-1-piperazinyl]pyrrolidine-2,5-dione | [no description available] | low | 0 | 0 | piperazines | |
| 4-(diethylamino)benzoic acid [2-oxo-2-(4-phenyl-1-piperazinyl)ethyl] ester | [no description available] | low | 0 | 0 | piperazines | |
| 2-chloro-N-[5-chloro-2-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| 7-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]-2-hydroxypropoxy]-4-methyl-1-benzopyran-2-one | [no description available] | low | 0 | 0 | piperazines | |
| 3-[(4-phenyl-1-piperazinyl)sulfonyl]benzoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | piperazines | |
| pramiconazole | [no description available] | low | 0 | 0 | piperazines | |
| 4-[4-[[1-(2-methylbutan-2-yl)-5-tetrazolyl]-(6-quinolinyl)methyl]-1-piperazinyl]phenol | [no description available] | low | 0 | 0 | piperazines | |
| 1-[3-methyl-1-[1-[(4-methylphenyl)sulfonylmethyl]-5-tetrazolyl]butyl]-4-phenylpiperazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-[4-(4-fluorophenyl)-2-thiazolyl]-1-piperazinyl]-1-[4-(4-methoxyphenyl)-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 3-[(2-chlorophenyl)methyl]-7-[4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]triazolo[4,5-d]pyrimidine | [no description available] | low | 0 | 0 | piperazines | |
| 4-[4-[(1-tert-butyl-5-tetrazolyl)-pyridin-4-ylmethyl]-1-piperazinyl]phenol | [no description available] | low | 0 | 0 | piperazines | |
| 2-[(3-fluorophenyl)methylthio]-1-(4-phenyl-1-piperazinyl)ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-methyl-4-[[2-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]thio]-2-quinolinone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N-[3-[4-(2,3-dimethylphenyl)-1-piperazinyl]-3-oxopropyl]-2-(1-oxo-2-isoquinolinyl)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 6-bromo-3-[4-oxo-4-[4-(2-pyridinyl)-1-piperazinyl]butyl]-2-sulfanylidene-1H-quinazolin-4-one | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 3-chloro-N-[2-[4-(4-fluorophenyl)-1-piperazinyl]-2-(3-pyridinyl)ethyl]benzamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-(4-methyl-2-prop-2-enylphenoxy)-3-(4-phenyl-1-piperazinyl)-2-propanol | [no description available] | low | 0 | 0 | piperazines | |
| 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione | [no description available] | low | 0 | 0 | piperazines | |
| N-[4-[[4-(2-fluorophenyl)-1-piperazinyl]-oxomethyl]-1-oxo-2-isoquinolinyl]-2-pyrazinecarboxamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[4-methyl-2-(4-methyl-1-piperazinyl)-6-quinolinyl]-1,3-benzodioxole-5-carboxamide | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 4-[2-(1-cyclohexenyl)ethyl]-1-cyclohexyl-3-pyridin-4-ylpiperazine-2,5-dione | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 2-[[3-oxo-2-[3-oxo-3-(4-phenyl-1-piperazinyl)propyl]-2H-imidazo[1,2-c]quinazolin-5-yl]thio]acetonitrile | [no description available] | low | 0 | 0 | piperazines | |
| [5-(3-chlorophenyl)-3-isoxazolyl]-[4-(2-methoxyphenyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-[3-[4-(2-fluorophenyl)-1-piperazinyl]propyl]-3-[4-(methylthio)phenyl]urea | [no description available] | low | 0 | 0 | piperazines | |
| ml012 | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N-[2-[4-(3-chlorophenyl)-1-piperazinyl]ethyl]-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine | [no description available] | low | 0 | 0 | piperazines | |
| N-[2-[4-(4-fluorophenyl)-1-piperazinyl]-2-(3-pyridinyl)ethyl]cyclohexanecarboxamide | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2-pyrimidinyl)-1-piperazinyl]-[1-[4-(2-pyrimidinyl)-1-piperazinyl]-4-isoquinolinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N-[3-cyano-4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]cyclohexanecarboxamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-2-[(1-ethyl-2-oxo-4-quinolinyl)oxy]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-(2-furanylmethyl)-N'-[4-methyl-2-(4-methyl-1-piperazinyl)-6-quinolinyl]butanediamide | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 7-[4-[4-(2-fluorophenyl)-1-piperazinyl]-4-oxobutyl]-6-sulfanylidene-5H-[1,3]dioxolo[4,5-g]quinazolin-8-one | [no description available] | low | 0 | 0 | piperazines | |
| 8-[[4-(5-chloro-2-methylphenyl)-1-piperazinyl]methyl]-3-methyl-7-(2-phenylethyl)purine-2,6-dione | [no description available] | low | 0 | 0 | piperazines | |
| N-(2-fluorophenyl)-3-[4-(2-fluorophenyl)-1-piperazinyl]propanamide | [no description available] | low | 0 | 0 | piperazines | |
| sb 258585 | [no description available] | low | 0 | 0 | piperazines | |
| [3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| (4-methylphenyl)-[4-[4-nitro-3-(3-pyridinylmethylamino)phenyl]-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| N-[3-[4-(4-fluorophenyl)-1-piperazinyl]-1,4-dioxo-2-naphthalenyl]benzenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| [3-(2,3-dihydroindol-1-ylsulfonyl)phenyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 3-(4-benzoyl-1-piperazinyl)-1-(2-methylpropyl)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| rs 100329 | [no description available] | low | 0 | 0 | piperazines | |
| 2-methyl-5-[(4-phenyl-1-piperazinyl)-(3,4,5-trimethoxyphenyl)methyl]-6-thiazolo[3,2-b][1,2,4]triazolol | [no description available] | low | 0 | 0 | piperazines | |
| N-[[4-[[4-(4-fluorophenyl)-1-piperazinyl]-oxomethyl]cyclohexyl]methyl]-2-thiophenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| pd 168,077 | [no description available] | low | 0 | 0 | piperazines | |
| N-[3-[4-(3-chlorophenyl)-1-piperazinyl]-1,4-dioxo-2-naphthalenyl]-2-thiophenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[3-(4-methyl-1-piperazinyl)-1,4-dioxo-2-naphthalenyl]benzenesulfonamide | [no description available] | low | 0 | 0 | 1,4-naphthoquinones; piperazines; sulfonamide | |
| 5-cyano-6-[4-(4-methoxyphenyl)-1-piperazinyl]-2-oxo-1H-pyridine-3-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 2-[4-(3-chlorophenyl)-1-piperazinyl]-3-pyridinecarboxylic acid propan-2-yl ester | [no description available] | low | 0 | 0 | isopropyl ester; piperazines; pyridines | |
| N-[3-fluoro-4-(4-phenyl-1-piperazinyl)phenyl]-2-(4-morpholinyl)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 3-(3,5-dimethyl-1-pyrazolyl)-6-[4-(4-fluorophenyl)-1-piperazinyl]-1,2,4,5-tetrazine | [no description available] | low | 0 | 0 | piperazines | |
| 2-(4-phenyl-1-piperazinyl)quinoxaline | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-(3-chlorophenyl)-1-piperazinyl]-2-phenyl-1-butanone | [no description available] | low | 0 | 0 | piperazines | |
| 6-amino-5-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-oxoethyl]-1,3-dimethylpyrimidine-2,4-dione | [no description available] | low | 0 | 0 | piperazines | |
| mm 77 | [no description available] | low | 0 | 0 | piperazines | |
| 3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1,5-dihydropyrimido[5,4-b]indole-2,4-dione | [no description available] | low | 0 | 0 | piperazines; pyrimido-indole | |
| 4-(1H-benzimidazol-2-ylthio)-1-[4-(4-nitrophenyl)-1-piperazinyl]-1-butanone | [no description available] | low | 0 | 0 | piperazines | |
| [4-[(2-chlorophenyl)methylsulfonyl]-3-nitrophenyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-2-(3-pyridinyl)ethyl]-2-thiophenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| 2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-6,7,8,8a-tetrahydro-5H-imidazo[1,5-a]pyridine-1,3-dione | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2,3-dimethylphenyl)-1-piperazinyl]-[5-[(4-methoxyphenyl)sulfonylmethyl]-2-furanyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| (6-bromo-5-methoxy-2-methyl-3-benzofuranyl)-[4-(2-methylphenyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| 3-[3-[4-(4-methoxyphenyl)-1-piperazinyl]propyl]-2-sulfanylidene-1H-pyrido[2,3-d]pyrimidin-4-one | [no description available] | low | 0 | 0 | piperazines | |
| N-[4-chloro-3-(trifluoromethyl)phenyl]-2-[4-(2-methoxyphenyl)-1-piperazinyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[[4-(2-ethoxyphenyl)-1-piperazinyl]-sulfanylidenemethyl]-1-adamantanecarboxamide | [no description available] | low | 0 | 0 | piperazines | |
| 3-(4-ethylphenyl)-4-hydroxy-4-[oxo-[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-quinazolin-2-one | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 5-[(4-phenyl-1-piperazinyl)-thiophen-2-ylmethyl]-6-thiazolo[3,2-b][1,2,4]triazolol | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(5-chloro-2-methylphenyl)-1-piperazinyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-(2-fluorophenyl)-1-piperazinyl]-4-(4,4,6-trimethyl-2-sulfanylidene-1,3-diazinan-1-yl)-1-butanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-(2-chloro-4-nitrophenyl)-4-(2-methoxyphenyl)piperazine | [no description available] | low | 0 | 0 | piperazines | |
| N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-N-ethyl-2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N,N-dimethyl-3-[[4-(4-nitrophenyl)-1-piperazinyl]-oxomethyl]-4-(1-pyrrolidinyl)benzenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| 4-methyl-7-[[4-[[4-(4-nitrophenyl)-1-piperazinyl]-oxomethyl]phenyl]methoxy]-1-benzopyran-2-one | [no description available] | low | 0 | 0 | piperazines | |
| abt724 | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-[4-(2,3-dimethylphenyl)-1-piperazinyl]-3-(4,4,6-trimethyl-2-sulfanylidene-1,3-diazinan-1-yl)-1-propanone | [no description available] | low | 0 | 0 | piperazines | |
| 2-[(1-methyl-3-indolyl)thio]-1-(4-phenyl-1-piperazinyl)ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(4-chloro-2-nitrophenyl)-1-piperazinyl]phenol | [no description available] | low | 0 | 0 | piperazines | |
| 2-(4-acetyl-1-piperazinyl)-6-amino-4-(cyanomethyl)pyridine-3,5-dicarbonitrile | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| [2-(1-piperidinyl)-1,3-benzothiazol-6-yl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| [4-(3-methoxyphenyl)-1-piperazinyl]-[2-(1-piperidinyl)-1,3-benzothiazol-6-yl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| N-[3-[4-(2,5-dimethylphenyl)-1-piperazinyl]propyl]-2-(6-methyl-3-oxo-4H-1,4-benzoxazin-2-yl)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| N-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-2-pyrazinecarboxamide | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 6-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-3-(phenylmethyl)-7-triazolo[4,5-d]pyrimidinone | [no description available] | low | 0 | 0 | piperazines | |
| N-[1-[4-(2-methoxyphenyl)-1-piperazinyl]-1-thiophen-2-ylpropan-2-yl]benzenesulfonamide | [no description available] | low | 0 | 0 | piperazines | |
| l 745870 | [no description available] | low | 0 | 0 | piperazines | |
| kn 62 | [no description available] | low | 0 | 0 | piperazines | |
| (5R)-3'-phenyl-1-(phenylmethyl)spiro[1,3-diazinane-5,5'-2,4,4a,6-tetrahydro-1H-pyrazino[1,2-a]quinoline]-2,4,6-trione | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-[4-[[(2R)-2-(2,4-dichlorophenyl)-2-(1-imidazolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| [4-(3-chlorophenyl)sulfonyl-3-nitrophenyl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N-[2-(4-acetyl-1-piperazinyl)phenyl]-2-(2-methylphenoxy)acetamide | [no description available] | low | 0 | 0 | piperazines | |
| (4-chloro-2-methyl-3-pyrazolyl)-[4-(2-ethoxyphenyl)-1-piperazinyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| l 750667 | [no description available] | low | 0 | 0 | piperazines | |
| 2-[4-(2-pyrimidinyl)-1-piperazinyl]quinoline | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 3-(1H-benzimidazol-2-yl)-1-[4-(2,4-dimethylphenyl)-1-piperazinyl]-1-propanone | [no description available] | low | 0 | 0 | piperazines | |
| LSM-17022 | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-(2,3-dimethylphenyl)-1-piperazinyl]-2-(1-methyl-3-indolyl)ethanone | [no description available] | low | 0 | 0 | piperazines | |
| pnu 96415e | [no description available] | low | 0 | 0 | piperazines | |
| n-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2h)-carboxamide | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| [4-(3-chlorophenyl)-1-piperazinyl]-(5-methyl-2-phenyl-3-pyrazolyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| PB28 | [no description available] | low | 0 | 0 | aromatic ether; piperazines; tetralins | anticoronaviral agent; antineoplastic agent; apoptosis inducer; sigma-2 receptor agonist |
| danusertib | [no description available] | low | 0 | 0 | piperazines | |
| hydroxynefazodone | [no description available] | low | 0 | 0 | piperazines | |
| N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]carbamic acid (2,6-dimethylphenyl) ester | [no description available] | low | 0 | 0 | piperazines | |
| 2-[2-fluoro-5-(4-methyl-1-piperazinyl)-4-nitrophenyl]-3,4-dihydro-1H-isoquinoline | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-[3-methyl-4-(3-methylphenyl)-1-piperazinyl]-3-nitrophenyl]piperidine-2,6-dione | [no description available] | low | 0 | 0 | piperazines | |
| [3-methyl-4-(3-methylphenyl)-1-piperazinyl]-[1-(7,8,9,10-tetrahydro-6H-purino[9,8-a]azepin-4-yl)-4-piperidinyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| [4-(2,3-dimethylphenyl)-1-piperazinyl]-[5-[(4-methylphenyl)sulfonylmethyl]-2-furanyl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| [4-(3-chlorophenyl)-1-piperazinyl]-[1-[4-(2-pyridinyl)-1-piperazinyl]-4-isoquinolinyl]methanone | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| 1-butyl-3-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-1-methylthiourea | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| N-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-6-sulfanylidene-5H-benzimidazolo[1,2-c]quinazoline-3-carboxamide | [no description available] | low | 0 | 0 | piperazines | |
| 1-[5-(diethylsulfamoyl)-2-(4-methyl-1-piperazinyl)phenyl]-3-(2-fluorophenyl)urea | [no description available] | low | 0 | 0 | piperazines | |
| 8-[1-(1,3-benzodioxol-5-yl)-3-(4-phenyl-1-piperazinyl)propyl]-5,7-dimethoxy-4-methyl-1-benzopyran-2-one | [no description available] | low | 0 | 0 | piperazines | |
| gdc 0941 | [no description available] | low | 0 | 0 | indazoles; morpholines; piperazines; sulfonamide; thienopyrimidine | EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor |
| 4-[4-(4-fluorophenyl)-1-piperazinyl]-N-[4-methyl-2-(4-morpholinyl)-6-quinolinyl]-4-oxobutanamide | [no description available] | low | 0 | 0 | piperazines | |
| cyclopropyl-[5-[[4-[[4-(2-methoxyphenyl)-1-piperazinyl]-oxomethyl]-1-piperidinyl]sulfonyl]-2-methyl-2,3-dihydroindol-1-yl]methanone | [no description available] | low | 0 | 0 | piperazines | |
| [5-[(2-methoxyphenoxy)methyl]-3-isoxazolyl]-(4-methyl-3-phenyl-1-piperazinyl)methanone | [no description available] | low | 0 | 0 | piperazines | |
| mk-1775 | [no description available] | low | 0 | 0 | piperazines | |
| navitoclax | [no description available] | low | 0 | 0 | aryl sulfide; monochlorobenzenes; morpholines; N-sulfonylcarboxamide; organofluorine compound; piperazines; secondary amino compound; sulfone; tertiary amino compound | antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor |
| 1-[4-[4-(2-furanylmethylamino)phenyl]-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| 1-[4-[4-[(5-bromo-2-furanyl)methylamino]phenyl]-1-piperazinyl]ethanone | [no description available] | low | 0 | 0 | piperazines | |
| N-[3-[[5-chloro-2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide | [no description available] | low | 0 | 0 | piperazines | |
| thiopental sodium | [no description available] | low | 0 | 0 | organochlorine compound; piperazines; pyrimidines | antineoplastic agent; tyrosine kinase inhibitor |
| LSM-2536 | [no description available] | low | 0 | 0 | piperazines | |
| N-(4,6-dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamide | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| gsk-2816126 | [no description available] | low | 0 | 0 | piperazines; pyridines | |
| sildenafil | [no description available] | low | 0 | 0 | piperazines; pyrazolopyrimidine; sulfonamide | EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor; vasodilator agent |
| norclozapine | [no description available] | low | 0 | 0 | dibenzodiazepine; organochlorine compound; piperazines | delta-opioid receptor agonist; metabolite; serotonergic antagonist |
| 3-cyanopyridine | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| 2-(3-pyridine)acetic acid | [no description available] | low | 0 | 0 | monocarboxylic acid; pyridines | human xenobiotic metabolite |
| nicotine 1-n-oxide | [no description available] | low | 0 | 0 | pyridines; pyrrolidine N-oxides | |
| norcotinine | [no description available] | low | 0 | 0 | pyridines; pyrrolidines | |
| 4-oxo-4-(3-pyridyl)butanoic acid | [no description available] | low | 0 | 0 | aromatic ketone; monocarboxylic acid; pyridines | |
| pyridine | [no description available] | low | 0 | 0 | azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines | environmental contaminant; NMR chemical shift reference compound |
| carbinoxamine | [no description available] | low | 0 | 0 | monochlorobenzenes; pyridines; tertiary amino compound | anti-allergic agent; antiparkinson drug; H1-receptor antagonist; muscarinic antagonist |
| chlorpheniramine | [no description available] | low | 0 | 0 | monochlorobenzenes; pyridines; tertiary amino compound | anti-allergic agent; antidepressant; antipruritic drug; H1-receptor antagonist; histamine antagonist; serotonin uptake inhibitor |
| disopyramide | [no description available] | low | 0 | 0 | monocarboxylic acid amide; pyridines; tertiary amino compound | anti-arrhythmia drug |
| doxylamine | [no description available] | low | 0 | 0 | pyridines; tertiary amine | anti-allergic agent; antiemetic; antitussive; cholinergic antagonist; H1-receptor antagonist; histamine antagonist; sedative |
| fusaric acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| iproniazid | [no description available] | low | 0 | 0 | carbohydrazide; pyridines | |
| lansoprazole | [no description available] | low | 0 | 0 | benzimidazoles; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| entinostat | [no description available] | low | 0 | 0 | benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline | antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor |
| niflumic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| omeprazole | [no description available] | low | 0 | 0 | aromatic ether; benzimidazoles; pyridines; sulfoxide | |
| pantoprazole | [no description available] | low | 0 | 0 | aromatic ether; benzimidazoles; organofluorine compound; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; environmental contaminant; xenobiotic |
| pheniramine | [no description available] | low | 0 | 0 | pyridines; tertiary amino compound | |
| pinacidil | [no description available] | low | 0 | 0 | pyridines | |
| pioglitazone | [no description available] | low | 0 | 0 | aromatic ether; pyridines; thiazolidinediones | antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic |
| pirbuterol | [no description available] | low | 0 | 0 | pyridines | |
| pyridinolcarbamate | [no description available] | low | 0 | 0 | pyridines | |
| rabeprazole | [no description available] | low | 0 | 0 | benzimidazoles; pyridines; sulfoxide | anti-ulcer drug; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor |
| sb 202190 | [no description available] | low | 0 | 0 | imidazoles; organofluorine compound; phenols; pyridines | apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| risedronic acid | [no description available] | low | 0 | 0 | pyridines | |
| imatinib | [no description available] | low | 0 | 0 | aromatic amine; benzamides; N-methylpiperazine; pyridines; pyrimidines | antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor |
| streptonigrin | [no description available] | low | 0 | 0 | pyridines; quinolone | antimicrobial agent; antineoplastic agent |
| sulfapyridine | [no description available] | low | 0 | 0 | pyridines; substituted aniline; sulfonamide antibiotic; sulfonamide | antiinfective agent; dermatologic drug; drug allergen; environmental contaminant; xenobiotic |
| tazarotene | [no description available] | low | 0 | 0 | acetylenic compound; ethyl ester; pyridines; retinoid; thiochromane | keratolytic drug; prodrug; teratogenic agent |
| n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine | [no description available] | low | 0 | 0 | N-substituted diamine; pyridines; tertiary amino compound | apoptosis inducer; chelator; copper chelator |
| thurfyl nicotinate | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| brompheniramine | [no description available] | low | 0 | 0 | organobromine compound; pyridines | anti-allergic agent; H1-receptor antagonist |
| methyl nicotinate | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| citrazinic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| nicotinyl alcohol | [no description available] | low | 0 | 0 | aromatic primary alcohol; pyridines | antilipemic drug; vasodilator agent |
| beta-nicotyrine | [no description available] | low | 0 | 0 | pyridines | |
| 3-ethylpyridine | [no description available] | low | 0 | 0 | pyridines | |
| 2-Pyridinylmethanol | [no description available] | low | 0 | 0 | pyridines | |
| nicoboxil | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| clopyralid | [no description available] | low | 0 | 0 | organochlorine pesticide; pyridines | herbicide |
| oxiniacic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-(aminomethyl)pyridine | [no description available] | low | 0 | 0 | pyridines | |
| propiram | [no description available] | low | 0 | 0 | pyridines | |
| n'-nitrosonornicotine | [no description available] | low | 0 | 0 | pyridines; pyrrolidines | |
| 5-hydroxynicotinic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| n-cyano-n'-(1,1-dimethylpropyl)-n''-(3-pyridinyl)guanidine | [no description available] | low | 0 | 0 | pyridines | |
| 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone | [no description available] | low | 0 | 0 | nitrosamine; pyridines | |
| haloxyfop | [no description available] | low | 0 | 0 | aromatic ether; monocarboxylic acid; organochlorine compound; organofluorine compound; pyridines | |
| fluazifop-butyl | [no description available] | low | 0 | 0 | aromatic ether; carboxylic ester; organofluorine compound; pyridines | |
| imazapyr, (+-)-isomer | [no description available] | low | 0 | 0 | imidazolines; imidazolone; pyridinemonocarboxylic acid; pyridines | |
| imazethapyr | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2,2'-dipyridyl disulfide | [no description available] | low | 0 | 0 | organic disulfide; pyridines | oxidising agent |
| droxicam | [no description available] | low | 0 | 0 | organic heterotricyclic compound; pyridines | cyclooxygenase 1 inhibitor; hepatotoxic agent; non-narcotic analgesic; non-steroidal anti-inflammatory drug; platelet aggregation inhibitor; prodrug |
| methyridine | [no description available] | low | 0 | 0 | pyridines | |
| picosulfate sodium | [no description available] | low | 0 | 0 | aryl sulfate; pyridines | |
| 2-hydroxynicotinic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| ethylnicotinate | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| nicametate | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| nicotinamide n-oxide | [no description available] | low | 0 | 0 | pyridines | |
| nicosulfuron | [no description available] | low | 0 | 0 | N-sulfonylurea; pyridines; pyrimidines | environmental contaminant; herbicide; xenobiotic |
| 4,4'-dipyridyl disulfide | [no description available] | low | 0 | 0 | organic disulfide; pyridines | |
| 2-Chloronicotinic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 4-methoxymethylpyridoxine | [no description available] | low | 0 | 0 | pyridines | |
| 6-chloronicotinic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-pyridylacetic acid | [no description available] | low | 0 | 0 | pyridines | |
| fluazifop | [no description available] | low | 0 | 0 | aromatic ether; monocarboxylic acid; organofluorine compound; pyridines | |
| pyriproxyfen | [no description available] | low | 0 | 0 | aromatic ether; pyridines | juvenile hormone mimic |
| dithiopyr | [no description available] | low | 0 | 0 | organofluorine compound; pyridines; thioester | |
| thiazopyr | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| dpx e9636 | [no description available] | low | 0 | 0 | aromatic ether; N-sulfonylurea; pyridines; pyrimidines; sulfone | environmental contaminant; herbicide; xenobiotic |
| clodinafop-propargyl | [no description available] | low | 0 | 0 | aromatic ether; carboxylic ester; organochlorine compound; organofluorine compound; propyzamide; pyridines | agrochemical; EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor; herbicide |
| flazasulfuron | [no description available] | low | 0 | 0 | pyridines; sulfonamide | |
| 2,6-dichloroisonicotinic acid | [no description available] | low | 0 | 0 | monocarboxylic acid; organochlorine compound; pyridines | EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor |
| difenpiramide | [no description available] | low | 0 | 0 | biphenyls; monocarboxylic acid amide; pyridines | antipyretic; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol | [no description available] | low | 0 | 0 | nitrosamine; pyridines; secondary alcohol | biomarker; carcinogenic agent; human urinary metabolite |
| hydroxycotinine | [no description available] | low | 0 | 0 | N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid | |
| 5-hydroxymethylomeprazole | [no description available] | low | 0 | 0 | aromatic ether; benzimidazoles; pyridines; sulfoxide | drug metabolite |
| forasartan | [no description available] | low | 0 | 0 | benzenes; pyridines; tetrazoles; triazoles | angiotensin receptor antagonist; antihypertensive agent |
| abiraterone | [no description available] | low | 0 | 0 | 3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; pyridines | antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor |
| agn 190299 | [no description available] | low | 0 | 0 | monocarboxylic acid; pyridines; retinoid; thiochromane | keratolytic drug; teratogenic agent |
| vatalanib | [no description available] | low | 0 | 0 | monochlorobenzenes; phthalazines; pyridines; secondary amino compound | angiogenesis inhibitor; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist |
| metyrapol | [no description available] | low | 0 | 0 | pyridines | |
| sb 203580 | [no description available] | low | 0 | 0 | imidazoles; monofluorobenzenes; pyridines; sulfoxide | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent |
| aminopyralid | [no description available] | low | 0 | 0 | aromatic amine; organochlorine pesticide; pyridines | herbicide |
| dabigatran etexilate | [no description available] | low | 0 | 0 | aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; carboxylic ester; pyridines | anticoagulant; EC 3.4.21.5 (thrombin) inhibitor; prodrug |
| dabigatran | [no description available] | low | 0 | 0 | aromatic amide; benzimidazoles; beta-alanine derivative; carboxamidine; pyridines | anticoagulant; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; EC 3.4.21.5 (thrombin) inhibitor |
| alpha-(trichloromethyl)-4-pyridineethanol | [no description available] | low | 0 | 0 | pyridines | |
| 6-methyl-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| gant58 | [no description available] | low | 0 | 0 | pyridines | |
| 3-(3-pyridinyl)propanoic acid | [no description available] | low | 0 | 0 | pyridines | |
| rosoxacin | [no description available] | low | 0 | 0 | pyridines; quinolinemonocarboxylic acid; quinolone antibiotic | antibacterial drug; antiinfective agent |
| gant 61 | [no description available] | low | 0 | 0 | aminal; dialkylarylamine; pyridines; substituted aniline; tertiary amino compound | antineoplastic agent; apoptosis inducer; glioma-associated oncogene inhibitor; Hedgehog signaling pathway inhibitor |
| e 3040 | [no description available] | low | 0 | 0 | benzothiazoles; organic hydroxy compound; pyridines; secondary amino compound | anti-inflammatory drug; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; uricosuric drug |
| E3040 glucuronide | [no description available] | low | 0 | 0 | benzothiazoles; beta-D-glucosiduronic acid; pyridines; secondary amino compound | xenobiotic metabolite |
| cerivastatin | [no description available] | low | 0 | 0 | dihydroxy monocarboxylic acid; pyridines; statin (synthetic) | |
| hts 466284 | [no description available] | low | 0 | 0 | pyrazoles; pyridines; quinolines | TGFbeta receptor antagonist |
| prinomastat | [no description available] | low | 0 | 0 | aromatic ether; hydroxamic acid; pyridines; sulfonamide; thiomorpholines | antineoplastic agent; EC 3.4.24.35 (gelatinase B) inhibitor; matrix metalloproteinase inhibitor |
| 6-methyl-2-oxo-5-[oxo-(1-phenylethylamino)methyl]-1H-pyridine-3-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 5-(2-furanyl)-3-(3-pyridinyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | pyridines | |
| 1-(2-pyridin-4-yl-1-oxa-3,4-diazaspiro[4.6]undec-2-en-4-yl)ethanone | [no description available] | low | 0 | 0 | pyridines | |
| s 1033 | [no description available] | low | 0 | 0 | (trifluoromethyl)benzenes; imidazoles; pyridines; pyrimidines; secondary amino compound; secondary carboxamide | anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor |
| 2-pyridinecarboxylic acid [2-(2,3-dichloroanilino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| N-methyl-N-(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)-3-oxolanecarboxamide | [no description available] | low | 0 | 0 | pyridines | |
| 5-(4-propylcyclohexyl)-3-(3-pyridinyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | pyridines | |
| N-methyl-N-[5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl]-3-oxolanecarboxamide | [no description available] | low | 0 | 0 | pyridines | |
| 2-methoxy-N-methyl-N-[5-(2-pyridinyl)-1,3,4-thiadiazol-2-yl]acetamide | [no description available] | low | 0 | 0 | pyridines | |
| 6-hydroxy-1-(3-hydroxypropyl)-4-methyl-2-oxo-5-(1-piperidinylmethyl)-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| 5-ethyl-4,6-dimethyl-2-sulfanylidene-1H-pyridine-3-carbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| N-(4-{[2-(pyridin-3-yl)piperidin-1-yl]sulfonyl}phenyl)acetamide | [no description available] | low | 0 | 0 | acetamides; piperidines; pyridines; sulfonamide | |
| 2-(pyridin-4-yl)-4-(pyrrolidin-1-yl)quinazoline | [no description available] | low | 0 | 0 | pyridines; pyrrolidines; quinazolines | |
| prothionamide | [no description available] | low | 0 | 0 | pyridines | |
| 1-(4-methyl-1,2,5-oxadiazol-3-yl)-3-(3-pyridinyl)urea | [no description available] | low | 0 | 0 | pyridines | |
| N-(3-fluorophenyl)-2-(pyridin-4-yl)quinazolin-4-amine | [no description available] | low | 0 | 0 | aromatic amine; monofluorobenzenes; pyridines; quinazolines; secondary amino compound; substituted aniline | |
| 5-cyano-2-methyl-6-sulfanylidene-1H-pyridine-3-carboxylic acid ethyl ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-(1H-imidazol-1-yl)-5-(trifluoromethyl)pyridine | [no description available] | low | 0 | 0 | pyridines | |
| 5-(3-pyridinylmethyl)-1,3,5-triazinane-2-thione | [no description available] | low | 0 | 0 | pyridines | |
| 2-amino-5-ethyl-4-(2-furanyl)-6-propyl-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| 4-(methoxymethyl)-6-methyl-2-(2-methylanilino)-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| GS4012 free base | [no description available] | low | 0 | 0 | aryl sulfide; monomethoxybenzene; pyridines | VEGF activator |
| 5-(phenylmethyl)-3-(2-pyridinyl)-1,2,4-oxadiazole | [no description available] | low | 0 | 0 | pyridines | |
| cotinine | [no description available] | low | 0 | 0 | N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid | antidepressant; biomarker; human xenobiotic metabolite; plant metabolite |
| 2-(2-phenylethylthio)-3-pyridinecarboxylic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-(2,6-dichloroanilino)-3-pyridinesulfonamide | [no description available] | low | 0 | 0 | pyridines; sulfonamide | |
| 4-(4-chloroanilino)-3-pyridinesulfonamide | [no description available] | low | 0 | 0 | pyridines; sulfonamide | |
| 6-(2-oxopropylthio)-3-pyridinecarboxylic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 6-chloro-N-(2-hydroxyphenyl)-3-pyridinesulfonamide | [no description available] | low | 0 | 0 | pyridines; sulfonamide | |
| 3-(phenylmethyl)-6-pyridin-4-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | [no description available] | low | 0 | 0 | pyridines; triazolothiadiazole | |
| 5-bromo-6-chloro-N-(4-methyl-2-pyridinyl)-3-pyridinesulfonamide | [no description available] | low | 0 | 0 | pyridines; sulfonamide | |
| pyrabactin | [no description available] | low | 0 | 0 | naphthalenes; organobromine compound; pyridines; sulfonamide | abscisic acid receptor agonist; hormone; plant growth regulator |
| 1-ethyl-3-sulfanylidene-5,6,7,8-tetrahydro-2H-isoquinoline-4-carbonitrile | [no description available] | low | 0 | 0 | pyridines | |
| 6-tert-butyl-2-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| N,N-dibutyl-2-(pyridin-4-yl)quinazolin-4-amine | [no description available] | low | 0 | 0 | pyridines; quinazolines; tertiary amino compound | |
| 4,6-dimethyl-2-[3-(4-morpholinyl)propylamino]-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| 2-ethoxy-3-pyridinecarboxylic acid [2-[1-(2-furanylmethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| mcb-613 | [no description available] | low | 0 | 0 | cyclic ketone; enone; pyridines | antineoplastic agent; steroid receptor coactivator stimulator |
| 5,6-dichloro-3-pyridinecarboxylic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 4-pyridinecarboxylic acid [2-[1-(2-furanylmethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-oxo-1H-pyridine-3-carboxylic acid [2-(2,5-dimethyl-1-propyl-3-pyrrolyl)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-thiopyridine | [no description available] | low | 0 | 0 | aryl thiol; pyridines | allergen; fluorescence quencher |
| 2-(methylamino)-6-thiophen-2-yl-4-(trifluoromethyl)-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| 2-(1-piperidinyl)-6-thiophen-2-yl-4-(trifluoromethyl)-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| N-benzyl-N'-methyl-N-(pyridin-3-ylmethyl)thiourea | [no description available] | low | 0 | 0 | pyridines | |
| 3-Chloro-5-(trifluoromethyl)pyridine-2-carbothioamide | [no description available] | low | 0 | 0 | pyridines | |
| 2,6-dimethyl-4-(3-thienyl)pyridine-3,5-dicarboxylic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 5-cyano-2-(methoxymethyl)-6-sulfanylidene-1H-pyridine-3-carboxylic acid methyl ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| ethionamide | [no description available] | low | 0 | 0 | pyridines; thiocarboxamide | antilipemic drug; antitubercular agent; fatty acid synthesis inhibitor; leprostatic drug; prodrug |
| 2-(propylthio)nicotinic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 5-Chloro-2-hydroxy-4,6-dimethylnicotinonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| 3-[1-(2,4-dichlorophenyl)sulfonyl-2-pyrrolidinyl]pyridine | [no description available] | low | 0 | 0 | pyridines; pyrrolidines | |
| 2-oxo-4,6-dithiophen-2-yl-1H-pyridine-3-carbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| 6-(2,3-dihydro-1,4-benzodioxin-3-ylmethylamino)-N-ethyl-N-phenyl-3-pyridinesulfonamide | [no description available] | low | 0 | 0 | pyridines; sulfonamide | |
| alpha-nicotyrine | [no description available] | low | 0 | 0 | pyridines | |
| dapiprazole | [no description available] | low | 0 | 0 | N-alkylpiperazine; N-arylpiperazine; pyridines | alpha-adrenergic antagonist; antipsychotic agent; miotic; ophthalmology drug |
| glucitol hexanicotinate | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 6,8-difluoro-4-(pyridin-3-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline | [no description available] | low | 0 | 0 | organic heterotricyclic compound; organofluorine compound; pyridines; secondary amino compound | |
| N-(1,3-benzodioxol-5-ylmethyl)-N-[2-(cyclohexylamino)-2-oxo-1-pyridin-4-ylethyl]-2,2,2-trifluoroacetamide | [no description available] | low | 0 | 0 | benzodioxoles; pyridines; secondary carboxamide; tertiary carboxamide; trifluoroacetamide | |
| 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester | [no description available] | low | 0 | 0 | aryl sulfide; azole; isopropyl ester; oxadiazole; pyridines | |
| 2-pyridinecarboxylic acid [2-(5-chloro-2-thiophenyl)-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-[[2-[(2-methoxyphenyl)methylamino]-2-oxoethyl]thio]-3-pyridinecarboxylic acid [2-[(2-methoxyphenyl)methylamino]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 2-[(5-formyl-2-methoxyphenyl)methylthio]-3-pyridinecarboxylic acid | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 3-(1-hydroxy-5,5-dimethyl-4-phenyl-2H-imidazol-2-yl)pyridine | [no description available] | low | 0 | 0 | pyridines | |
| 2-pyridinecarboxylic acid [2-[2-(difluoromethoxy)anilino]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| hydroxypioglitazone | [no description available] | low | 0 | 0 | aromatic ether; pyridines; thiazolidinediones | human xenobiotic metabolite |
| 2-(2-fluoroanilino)-3-pyridinecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)-methylamino]-2-oxoethyl] ester | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide | [no description available] | low | 0 | 0 | benzamides; benzodioxoles; imidazoles; pyridines | EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor |
| N-(1-benzylpiperidin-4-yl)-2-(pyridin-3-yl)quinazolin-4-amine | [no description available] | low | 0 | 0 | aromatic amine; piperidines; pyridines; quinazolines; secondary amino compound; tertiary amino compound | |
| triprolidine | [no description available] | low | 0 | 0 | N-alkylpyrrolidine; olefinic compound; pyridines | H1-receptor antagonist |
| pibutidine | [no description available] | low | 0 | 0 | aromatic ether; cyclobutenones; olefinic compound; piperidines; primary amino compound; pyridines; secondary amino compound | anti-ulcer drug; H2-receptor antagonist |
| acrivastine | [no description available] | low | 0 | 0 | alpha,beta-unsaturated monocarboxylic acid; N-alkylpyrrolidine; olefinic compound; pyridines | H1-receptor antagonist |
| 2-[3-(diethylamino)propylamino]-4-(methoxymethyl)-6-methyl-3-pyridinecarbonitrile | [no description available] | low | 0 | 0 | nitrile; pyridines | |
| clodinafop | [no description available] | low | 0 | 0 | aromatic ether; monocarboxylic acid; organochlorine compound; organofluorine compound; pyridines | EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor; phenoxy herbicide |
| 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | [no description available] | low | 0 | 0 | enone; pyridines | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; autophagy inducer; EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor |
| axitinib | [no description available] | low | 0 | 0 | aryl sulfide; benzamides; indazoles; pyridines | antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist |
| (2-Chloro-4-pyridinyl)methanol | [no description available] | low | 0 | 0 | organohalogen compound; pyridines | |
| pymetrozine | [no description available] | low | 0 | 0 | 1,2,4-triazines; pyridines | antifeedant; environmental contaminant; TRPV channel modulator; xenobiotic |
| abiraterone acetate | [no description available] | low | 0 | 0 | pyridines; sterol ester | antineoplastic agent; EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor; prodrug |
| mocetinostat | [no description available] | low | 0 | 0 | aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline | antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent |
| 4-(1H-imidazol-5-ylmethyl)pyridine | [no description available] | low | 0 | 0 | pyridines | |
| 680c91 | [no description available] | low | 0 | 0 | fluoroindole; olefinic compound; pyridines | EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor |
| masitinib | [no description available] | low | 0 | 0 | 1,3-thiazoles; benzamides; N-alkylpiperazine; pyridines | antineoplastic agent; antirheumatic drug; tyrosine kinase inhibitor |
| vorapaxar | [no description available] | low | 0 | 0 | carbamate ester; lactone; naphthofuran; organofluorine compound; pyridines | cardiovascular drug; platelet aggregation inhibitor; protease-activated receptor-1 antagonist |
| azd2858 | [no description available] | low | 0 | 0 | aromatic amine; N-methylpiperazine; pyrazines; pyridines; secondary carboxamide; sulfonamide | antineoplastic agent; bone density conservation agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; Wnt signalling activator |
| ciclonicate | [no description available] | low | 0 | 0 | aromatic carboxylic acid; pyridines | |
| tedizolid | [no description available] | low | 0 | 0 | carbamate ester; organofluorine compound; oxazolidinone; primary alcohol; pyridines; tetrazoles | antimicrobial agent; drug metabolite; protein synthesis inhibitor |
| chlorantranilipole | [no description available] | low | 0 | 0 | monochlorobenzenes; organobromine compound; pyrazole insecticide; pyrazoles; pyridines; secondary carboxamide | ryanodine receptor agonist |
| picoxystrobin | [no description available] | low | 0 | 0 | aromatic ether; enoate ester; enol ether; methoxyacrylate strobilurin antifungal agent; organofluorine compound; pyridines | antifungal agrochemical; mitochondrial cytochrome-bc1 complex inhibitor |
| tedizolid phosphate | [no description available] | low | 0 | 0 | carbamate ester; organofluorine compound; oxazolidinone; phosphate monoester; pyridines; tetrazoles | antimicrobial agent; prodrug; protein synthesis inhibitor |
| dorsomorphin | [no description available] | low | 0 | 0 | aromatic ether; piperidines; pyrazolopyrimidine; pyridines | bone morphogenetic protein receptor antagonist; EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor |
| cyantraniliprole | [no description available] | low | 0 | 0 | nitrile; organobromine compound; organochlorine compound; pyrazole insecticide; pyridines; secondary carboxamide | ryanodine receptor agonist |
| GDC-0879 | [no description available] | low | 0 | 0 | indanes; ketoxime; primary alcohol; pyrazoles; pyridines | antineoplastic agent; B-Raf inhibitor |
| bgt226 | [no description available] | low | 0 | 0 | aromatic ether; imidazoquinoline; N-arylpiperazine; organofluorine compound; pyridines | antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor |
| dafadine C | [no description available] | low | 0 | 0 | aromatic amide; aromatic ether; difluorobenzene; isoxazoles; N-acylpiperidine; pyridines | P450 inhibitor |
| dafadine B | [no description available] | low | 0 | 0 | aromatic amide; aromatic ether; isoxazoles; monochlorobenzenes; monofluorobenzenes; N-acylpiperidine; pyridines | P450 inhibitor |
| lumacaftor | [no description available] | low | 0 | 0 | aromatic amide; benzodioxoles; benzoic acids; cyclopropanes; organofluorine compound; pyridines | CFTR potentiator; orphan drug |
| ro5126766 | [no description available] | low | 0 | 0 | aryloxypyrimidine; coumarins; organofluorine compound; pyridines; sulfamides | antineoplastic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| sulfoxaflor | [no description available] | low | 0 | 0 | nitrile; organofluorine compound; pyridines; sulfoximide | |
| cnf 2024 | [no description available] | low | 0 | 0 | 2-aminopurines; aromatic ether; organochlorine compound; pyridines | antineoplastic agent; Hsp90 inhibitor |
| gdc 0449 | [no description available] | low | 0 | 0 | benzamides; monochlorobenzenes; pyridines; sulfone | antineoplastic agent; Hedgehog signaling pathway inhibitor; SMO receptor antagonist; teratogenic agent |
| bms 754807 | [no description available] | low | 0 | 0 | pyrazoles; pyridines; pyrrolidines; pyrrolotriazine | antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor |
| 4-(1-((5-((2,6-dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine | [no description available] | low | 0 | 0 | aromatic amide; aromatic ether; isoxazoles; N-acylpiperidine; pyridines | geroprotector; P450 inhibitor |
| dafadine D | [no description available] | low | 0 | 0 | aromatic amide; aromatic ether; isoxazoles; N-acylpiperidine; organofluorine compound; pyridines | P450 inhibitor |
| dafadine O | [no description available] | low | 0 | 0 | aromatic amide; aromatic ether; isoxazoles; N-acylpiperidine; pyridines; ring assembly | P450 inhibitor |
| florbetapir f 18 | [no description available] | low | 0 | 0 | (18)F radiopharmaceutical; aromatic ether; organofluorine compound; pyridines; substituted aniline | radioactive imaging agent |
| sch772984 | [no description available] | low | 0 | 0 | biaryl; indazoles; N-acylpiperazine; N-alkylpyrrolidine; N-arylpiperazine; pyridines; pyrimidines; pyrrolidinecarboxamide; secondary carboxamide; tertiary amino compound; tertiary carboxamide | analgesic; antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| gsk 2126458 | [no description available] | low | 0 | 0 | aromatic ether; difluorobenzene; pyridazines; pyridines; quinolines; sulfonamide | anticoronaviral agent; antineoplastic agent; autophagy inducer; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; mTOR inhibitor; radiosensitizing agent |
| 1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-(2-pyridinylsulfonyl)piperazine | [no description available] | low | 0 | 0 | pyridines; sulfonamide | |
| ml228 probe | [no description available] | low | 0 | 0 | 1,2,4-triazines; biphenyls; pyridines; secondary amino compound | hypoxia-inducible factor pathway activator |
| lgk974 | [no description available] | low | 0 | 0 | bipyridines; pyrazines; pyridines; secondary carboxamide | Wnt signalling inhibitor |
| afidopyropen | [no description available] | low | 0 | 0 | cyclopropanecarboxylate ester; organic heterotetracyclic compound; pyridines; secondary alcohol | agrochemical; insecticide; TRPV channel modulator |
| piroxicam | [no description available] | low | 0 | 0 | benzothiazine; monocarboxylic acid amide; pyridines | analgesic; antirheumatic drug; cyclooxygenase 1 inhibitor; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-steroidal anti-inflammatory drug |
| mobiflex | [no description available] | low | 0 | 0 | heteroaryl hydroxy compound; monocarboxylic acid amide; pyridines; thienothiazine | antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| lornoxicam | [no description available] | low | 0 | 0 | heteroaryl hydroxy compound; monocarboxylic acid amide; organochlorine compound; pyridines; thienothiazine | antipyretic; non-narcotic analgesic; non-steroidal anti-inflammatory drug |
| MK-8353 | [no description available] | low | 0 | 0 | aromatic ether; dihydropyridine; indazoles; methyl sulfide; N-alkylpyrrolidine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; triazoles | antineoplastic agent; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor |
| acp-196 | [no description available] | low | 0 | 0 | aromatic amine; benzamides; imidazopyrazine; pyridines; pyrrolidinecarboxamide; secondary carboxamide; tertiary carboxamide; ynone | antineoplastic agent; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor |
| GSK1059615 | [no description available] | low | 0 | 0 | pyridines; quinolines; thiazolidinone | antineoplastic agent; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor |
| pf-06687252 | [no description available] | low | 0 | 0 | azabicycloalkane; enone; phenols; pyridines | |
| 2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1h-indole-5-carbonitrile | [no description available] | low | 0 | 0 | hydroxyindoles; morpholines; nitrile; pyridines; tertiary amino compound | antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; tau aggregation inhibitor |
| sb-590885 | [no description available] | low | 0 | 0 | aromatic ether; imidazoles; ketoxime; pyridines; tertiary amino compound |
| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|---|---|---|---|
| Encephalitis, Polio | 0 | low | 1 | 0 |
| Epidemic Acute Poliomyelitis | 0 | low | 1 | 0 |
| Infantile Paralysis | 0 | low | 1 | 0 |
| Inflammation | 0 | low | 1 | 0 |
| Innate Inflammatory Response | 0 | low | 1 | 0 |
| Polio | 0 | low | 1 | 0 |
| Polio Encephalitis | 0 | low | 1 | 0 |
| Poliomyelitis | 0 | low | 1 | 0 |
| Poliomyelitis Infection | 0 | low | 1 | 0 |
| Poliomyelitis, Acute | 0 | low | 1 | 0 |
| Poliomyelitis, Nonpoliovirus | 0 | low | 1 | 0 |
| Poliomyelitis, Preparalytic | 0 | low | 1 | 0 |